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PhytoflORAL™

Beauty from Within

Super fruit power for brighter and healthy glowing skin

A natural beauty dietary ingredient from tomato, rich in rare, UV-absorbing, colorless carotenoids (phytoene and phytofluene), it provides skin with patented, optimized protection against damage induced by internal free radicals, making the skin appear more radiant, lighter and youthful.

Skin health reflects inner health

Nutrition plays a major role in maintaining skin health. Supplementation with key nutrients, including carotenoids, can complement a whole-body approach to beauty. Carotenoids are potent, free-radical scavengers. Their structure, physicochemical properties, and activities have evolved to play key roles in photosynthesis. They absorb sunlight energy and mitigate related photodamage—high interest in cosmetic applications.

Phytoene and phytofluene – the “undercover” colorless carotenoids

Phytoene and phytofluene are the precursors of all colored carotenoids and therefore bring the same benefits including anti-oxidative, DNA protection, and anti-inflammatory effects. However, they absorb light in the UV range and appear colorless. Their potential in nutricosmetics was understudied.

When compared to colored carotenoids, their unique structure gives them superior properties beyond light absorbance, including reduced susceptibility to oxidation and increased bioavailability.

Mode of action

Feeding the skin with our unique colorless carotenoids, acting as UV absorbents, free radical quenchers, and anti-inflammatory agents, is an effective photoprotective strategy for healthier-looking skin.

  • Improves cellular anti-oxidative and anti-inflammatory capacity
  • Quenches free radicals
  • Reduces melanin production via upregulation of melanogenesis inhibitor AZGP-1
  • Inhibits PGE2 production
  • Inhibits MMP-1 expression
The image compares the effects of sunlight exposure on skin versus the effects of a product or compound called PHYTOFLORAL™ on skin.

### Skin Exposed to Sunlight (Left Side):
- **Increased ROS (Reactive Oxygen Species):** Leads to oxidative stress.
- **Increased TYR (Tyrosinase):** Causes increased melanin production, resulting in brown spots and UV spots.
- **Increased PGE2:** Leads to increased inflammation, visible as red spots.
- **Increased MMPs (Matrix Metalloproteinases):** Causes ECM (extracellular matrix) degradation.
- **Visible Effects:** Wrinkles, loss of skin elasticity and firmness, loss of radiance, and increased dullness.

### PHYTOFLORAL™ (Right Side):
- **Modulates genes involved in optimal cellular anti-oxidative and anti-inflammatory capacity.**
- **Quenches free radicals.**
- **+126% Upregulates AZGP1 expression:** AZGP1 is likely involved in skin health.
- **-22% Inhibits melanin production:** Reduces brown spots and UV spots.
- **-47% Inhibits PGE2 production:** Reduces inflammation.
- **-16% Inhibits MMP-1 expression:** Prevents ECM degradation.

### Summary:
- Sunlight exposure causes oxidative stress, inflammation, increased melanin production, and ECM degradation, leading to skin aging signs like wrinkles, dullness, and spots.
- PHYTOFLORAL™ counteracts these effects by enhancing antioxidant and anti-inflammatory responses, reducing melanin production, inflammation, and ECM degradation, thereby promoting healthier skin.
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Clinically tested

Tested on Asian volunteers (skin phototype IV), daily consumption of 1g PhytoflORAL® improved skin brightening and luminosity for healthy glowing skin complexion.

The bar graph presents the evaluation of skin quality through clinical grading, focusing on five parameters: Hydration, Smoothness, Suppleness, Evenness, and Texture. The data is shown for two time points, Day 42 (D42) and Day 84 (D84), with D42 represented by a lighter yellow and D84 by a darker yellow.

Here's a summary of the findings:

1. **Hydration**: There is an improvement in hydration from D42 to D84, with both time points showing statistically significant improvements compared to the baseline (D0), as indicated by the double asterisk (**), which denotes a p-value of less than 0.01.

2. **Smoothness**: Smoothness shows a marked improvement over time, with D84 showing a higher increase than D42. Both time points are statistically significant, with D84 showing a higher level of significance (***), indicating a p-value of less than 0.001.

3. **Suppleness**: Suppleness shows the most significant improvement among the parameters, with D84 reaching close to 100% improvement. Both D42 and D84 are statistically significant, with D84 having a p-value of less than 0.001 (***).

4. **Evenness**: Evenness shows a moderate improvement, with D84 showing a greater increase than D42. Both time points are statistically significant, with D84 having a p-value of less than 0.001 (***).

5. **Texture**: Texture also shows improvement, with D84 showing a higher increase than D42. Both time points are statistically significant, with D84 having a p-value of less than 0.001 (***).

Overall, the graph indicates that skin quality improves over time across all parameters, with the most significant improvements observed by Day 84. The statistical significance suggests that these improvements are unlikely to be due to chance.

Proven results

Tested on Caucasian volunteers (skin phototype II), daily consumption of 1gr PhytoflORAL® improved skin photoprotection and skin quality parameters for healthy and youthful looking skin.

PhytoflORAL™– proprietary tomatoes from the Mediterranean

PhytoflORAL™ tomatoes were developed through selective breeding to create a tomato variety with a very unique phytochemical composition. Their color varies from deep yellow to orange to deep orange with a unique composition of carotenoids, including the colorless carotenoids phytoene and phytofluene (about 30% of the total carotenoids).

PhytoflORAL™ tomato powder Full traceability from field to beauty

100% freeze-dried tomato powder, chemically unprocessed, and preservative-free.

Delivers 500 times more bioaccessible amounts of the rare colorless carotenoids, phytoene and phytofluene, compared to fresh market red tomato. A result of years-long field research and & development that optimized tomato varieties.

Produced under dietary supplement GMP guidelines in an FDA-approved facility. It is Halal certified, and vegan compatible.

Seitenzusammenfassung

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